:root {
  --blue-950:#082f49; --blue-800:#075985; --blue-600:#0284c7; --teal-700:#0f766e; --teal-500:#14b8a6;
  --slate-950:#020617; --slate-800:#1e293b; --slate-600:#475569; --slate-300:#cbd5e1; --slate-200:#e2e8f0; --slate-100:#f1f5f9; --white:#fff;
  --rose:#dc2626; --amber:#b45309; --shadow:0 20px 60px rgba(15,23,42,.12); --radius:24px;
}
*{box-sizing:border-box} html{scroll-behavior:smooth} body{margin:0;font-family:Inter,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif;color:var(--slate-950);background:radial-gradient(circle at 5% 0%,rgba(20,184,166,.18),transparent 28rem),radial-gradient(circle at 95% 10%,rgba(2,132,199,.16),transparent 30rem),linear-gradient(180deg,#f8fbff 0%,#eef7f8 48%,#fff 100%);line-height:1.55} button,input,select,textarea{font:inherit} code{font-weight:800;color:var(--blue-800)}
.app-header{position:sticky;top:0;z-index:30;display:flex;align-items:center;justify-content:space-between;gap:18px;padding:12px clamp(16px,4vw,44px);background:rgba(255,255,255,.88);border-bottom:1px solid rgba(226,232,240,.92);backdrop-filter:blur(16px)}
.brand{display:flex;align-items:center;gap:10px;color:var(--blue-950);font-size:1.12rem;font-weight:900;text-decoration:none}.brand-mark{width:40px;height:40px;border-radius:13px;display:grid;place-items:center;color:#fff;background:linear-gradient(135deg,var(--teal-700),var(--blue-600));box-shadow:0 12px 24px rgba(2,132,199,.22)}
.top-nav{display:flex;align-items:center;gap:4px;flex-wrap:wrap;justify-content:flex-end}.top-nav a{padding:10px 12px;border-radius:999px;color:var(--slate-600);font-weight:750;text-decoration:none;font-size:.93rem}.top-nav a:hover,.top-nav a.active{color:var(--blue-800);background:#e0f2fe}.menu-toggle{display:none;border:0;background:var(--blue-800);color:#fff;border-radius:12px;padding:9px 12px}
main{width:min(1240px,calc(100% - 32px));margin:0 auto}.view{display:none;padding:34px 0 56px}.view.active{display:block}.hero-view{min-height:calc(100vh - 70px);align-content:center}.hero-grid{display:grid;grid-template-columns:minmax(0,1.12fr) minmax(320px,.88fr);gap:44px;align-items:center}.eyebrow{margin:0 0 10px;color:var(--teal-700);font-weight:900;letter-spacing:.12em;text-transform:uppercase;font-size:.78rem}.hero-copy h1{font-size:clamp(3.4rem,9vw,7rem);line-height:.88;margin:0;color:var(--blue-950);letter-spacing:-.075em}.hero-copy h2,.section-title h2{font-size:clamp(1.65rem,3vw,2.55rem);line-height:1.1;margin:14px 0;color:var(--slate-950)}.lead{font-size:1.15rem;color:var(--slate-600);max-width:780px}.quick-actions,.button-row{display:flex;flex-wrap:wrap;gap:12px;margin-top:18px}.button-row.stacked{align-items:flex-start}.btn{border:1px solid transparent;border-radius:999px;min-height:44px;padding:0 18px;display:inline-flex;align-items:center;justify-content:center;font-weight:850;cursor:pointer;text-decoration:none;transition:.2s ease}.btn:hover{transform:translateY(-1px)}.btn.primary{background:linear-gradient(135deg,var(--blue-800),var(--teal-700));color:white;box-shadow:0 14px 30px rgba(7,89,133,.24)}.btn.secondary{background:white;color:var(--blue-800);border-color:rgba(2,132,199,.28)}.btn.ghost{background:#f8fafc;color:var(--slate-800);border-color:var(--slate-200)}.btn.danger{background:var(--rose);color:#fff}.btn:disabled{opacity:.5;cursor:not-allowed}.file-label input{display:none}
.hero-panel,.card{background:rgba(255,255,255,.94);border:1px solid rgba(226,232,240,.95);border-radius:var(--radius);box-shadow:var(--shadow)}.hero-panel{padding:28px}.card{padding:24px;margin-bottom:22px}.status-pill{display:inline-flex;padding:8px 12px;border-radius:999px;background:#ccfbf1;color:var(--teal-700);font-weight:900}.local-flow{display:flex;gap:12px;align-items:center;justify-content:space-between;margin:24px 0;padding:18px;border-radius:18px;background:#f8fafc;color:var(--slate-600);font-weight:850}.hero-metrics,.metric-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}.hero-metrics div,.metric{padding:16px;border-radius:18px;background:linear-gradient(180deg,#fff,#f1f5f9);border:1px solid var(--slate-200)}.hero-metrics strong,.metric strong{display:block;color:var(--blue-950);font-size:1.4rem;line-height:1.1}.hero-metrics span,.metric span,.small,.muted{color:var(--slate-600);font-size:.9rem}.section-title{margin:18px 0 24px}.grid.two{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:22px}.check-list{padding-left:20px}.check-list li{margin:8px 0}.danger-card{border-color:#fecaca;background:#fff7f7}.alert{padding:14px 16px;border-radius:16px;margin:16px 0;border:1px solid}.alert.info{background:#eff6ff;border-color:#bfdbfe;color:#1e40af}.alert.warning{background:#fffbeb;border-color:#fde68a;color:#92400e}.alert.error{background:#fff1f2;border-color:#fecdd3;color:#9f1239}.message{margin-top:16px;font-weight:800;color:var(--teal-700)}
.form-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}.form-grid.compact{grid-template-columns:repeat(auto-fit,minmax(180px,1fr));align-items:end}.form-grid label{display:flex;flex-direction:column;gap:7px;color:var(--slate-800);font-weight:800}.form-grid .full{grid-column:1/-1}.checkbox{flex-direction:row!important;align-items:center;font-weight:700!important}.checkbox input{width:auto}input,select,textarea{width:100%;border:1px solid var(--slate-300);border-radius:14px;padding:11px 12px;background:white;color:var(--slate-950)}input:focus,select:focus,textarea:focus{outline:3px solid rgba(20,184,166,.2);border-color:var(--teal-500)}textarea{resize:vertical}.hidden{display:none}.summary-box{margin:16px 0}.table-wrap{width:100%;overflow:auto;margin-top:16px;border-radius:16px;border:1px solid var(--slate-200)}table{width:100%;border-collapse:collapse;background:white;font-size:.92rem}th,td{padding:11px 12px;border-bottom:1px solid var(--slate-200);text-align:left;vertical-align:top}th{background:#f8fafc;color:var(--blue-950);font-weight:900;position:sticky;top:0}tr:hover td{background:#f8fafc}.link-btn{border:0;background:transparent;color:var(--blue-800);font-weight:900;cursor:pointer;margin-right:8px}.danger-text{color:var(--rose)}
.metric-grid{grid-template-columns:repeat(4,minmax(0,1fr));margin-bottom:22px}.compact-metrics{grid-template-columns:repeat(auto-fit,minmax(140px,1fr));margin:12px 0}.chart-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:22px}.chart-grid .wide{grid-column:1/-1}.chart-grid canvas{min-height:260px;max-height:360px}#sankey-chart{min-height:380px}.timeline{margin-top:18px}.timeline-item{position:relative;margin:0 0 12px 14px;padding:12px 14px 12px 20px;border-left:4px solid var(--teal-500);background:#f8fafc;border-radius:14px}.timeline-item strong,.timeline-item span,.timeline-item small{display:block}.report-output{margin-top:18px}.report-card{padding:20px;border-radius:18px;background:#f8fafc;border:1px solid var(--slate-200)}.interpretation{padding:16px;border-radius:16px;background:#ecfeff;border:1px solid #a5f3fc;font-weight:750}.toast{position:fixed;right:20px;bottom:20px;max-width:min(460px,calc(100% - 40px));padding:14px 16px;border-radius:16px;color:white;background:var(--teal-700);box-shadow:var(--shadow);transform:translateY(120%);opacity:0;transition:.25s;z-index:60}.toast.show{transform:translateY(0);opacity:1}.toast.error{background:var(--rose)}
@media print{.app-header,.button-row,.quick-actions,.toast{display:none}.view{display:block;padding:0}.view:not(#informes){display:none}main{width:100%}.card{box-shadow:none;border:0}}
@media (max-width:900px){.menu-toggle{display:block}.top-nav{position:absolute;top:65px;right:16px;left:16px;display:none;flex-direction:column;align-items:stretch;background:white;border:1px solid var(--slate-200);border-radius:18px;padding:12px;box-shadow:var(--shadow)}.top-nav.open{display:flex}.hero-grid,.grid.two,.chart-grid{grid-template-columns:1fr}.hero-metrics,.metric-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.form-grid{grid-template-columns:1fr}.chart-grid .wide{grid-column:auto}}
@media (max-width:560px){main{width:min(100% - 20px,1240px)}.app-header{padding:10px}.hero-metrics,.metric-grid{grid-template-columns:1fr}.card,.hero-panel{padding:18px}.hero-copy h1{font-size:3.2rem}.btn{width:100%}}
.field-help{font-size:.86rem;color:var(--teal-700);font-weight:800}.field-warning{font-size:.86rem;color:#92400e;background:#fffbeb;border:1px solid #fde68a;border-radius:12px;padding:8px}.manual-dict-box{border:1px dashed var(--slate-300);border-radius:16px;padding:14px;background:#f8fafc}.manual-dict-box legend{font-weight:900;color:var(--blue-950);padding:0 8px}.cima-box p{margin:.4rem 0}.badge{display:inline-flex;border-radius:999px;padding:4px 9px;font-weight:900;font-size:.78rem}.badge.ok{background:#ccfbf1;color:var(--teal-700)}.badge.warning{background:#fffbeb;color:#92400e;border:1px solid #fde68a}
.tar-builder{border:1px solid var(--slate-200);border-radius:18px;padding:18px;background:#f8fafc}.tar-builder legend{font-weight:900;color:var(--blue-950);padding:0 8px}.tar-builder h4{margin:18px 0 8px;color:var(--blue-950)}.compact-row{margin:8px 0 12px}.cima-results{display:grid;gap:10px;margin:12px 0}.cima-result-card,.selected-med{display:flex;justify-content:space-between;gap:14px;align-items:flex-start;padding:12px;border:1px solid var(--slate-200);border-radius:14px;background:white}.cima-result-card strong,.selected-med strong{display:block;color:var(--slate-950)}.cima-result-card small,.selected-med small{display:block;margin-top:4px;color:var(--slate-600)}.selected-meds{display:grid;gap:10px;margin-bottom:12px}.manual-panel{border:1px dashed var(--slate-300);border-radius:14px;padding:14px;margin:12px 0;background:white}
@media (max-width:700px){.cima-result-card,.selected-med{flex-direction:column}.compact-row{align-items:stretch}}
.app-footer{width:min(1240px,calc(100% - 32px));margin:12px auto 28px;padding:24px;border:1px solid rgba(226,232,240,.95);border-radius:var(--radius);background:linear-gradient(135deg,rgba(8,47,73,.96),rgba(15,118,110,.94));color:white;box-shadow:var(--shadow)}.app-footer-grid{display:grid;grid-template-columns:1.1fr 1fr .9fr;gap:20px;align-items:stretch}.footer-block{padding:18px;border:1px solid rgba(255,255,255,.18);border-radius:20px;background:rgba(255,255,255,.1)}.footer-kicker{margin:0 0 8px;color:#a7f3d0;font-weight:950;letter-spacing:.12em;text-transform:uppercase;font-size:.74rem}.footer-block h2{margin:0 0 10px;font-size:1.12rem;line-height:1.15}.footer-block p{margin:0;color:rgba(255,255,255,.88)}.footer-block strong{color:#fff}.footer-telemetry dl{display:grid;gap:10px;margin:0}.footer-telemetry div{display:grid;gap:3px;padding:10px 12px;border-radius:14px;background:rgba(255,255,255,.12)}.footer-telemetry dt{color:#dbeafe;font-size:.82rem;font-weight:800}.footer-telemetry dd{margin:0;color:white;font-size:1.16rem;font-weight:950}.footer-essentials{display:flex;flex-wrap:wrap;gap:10px;margin-top:16px}.footer-essentials span{display:inline-flex;align-items:center;gap:6px;padding:8px 11px;border-radius:999px;background:rgba(255,255,255,.14);color:#fff;font-weight:850;font-size:.9rem}
@media print{.app-footer{display:none}}
@media (max-width:900px){.app-footer-grid{grid-template-columns:1fr}.app-footer{width:min(100% - 20px,1240px);padding:18px}}
.patient-suggestions{display:grid;gap:8px;margin:10px 0 4px}.patient-suggestion{width:100%;text-align:left;border:1px solid var(--slate-200);border-radius:14px;background:#f8fafc;color:var(--slate-800);padding:10px 12px;font-weight:800;cursor:pointer}.patient-suggestion:hover{background:#eff6ff;border-color:#bfdbfe;color:var(--blue-950)}
.economic-positive{--economic-color:#047857;--economic-bg:#ecfdf5;--economic-border:#a7f3d0}.economic-negative{--economic-color:#be123c;--economic-bg:#fff1f2;--economic-border:#fecdd3}.economic-neutral{--economic-color:#075985;--economic-bg:#eff6ff;--economic-border:#bfdbfe}.economic-warning{--economic-color:#b45309;--economic-bg:#fffbeb;--economic-border:#fde68a}.economic-global{padding:24px;margin:18px 0;border:2px solid var(--economic-border);border-radius:24px;background:linear-gradient(135deg,var(--economic-bg),#fff);box-shadow:var(--shadow)}.economic-global span{display:block;color:var(--economic-color);font-weight:950;letter-spacing:.08em;text-transform:uppercase;font-size:.8rem}.economic-global strong{display:block;margin:6px 0;color:var(--economic-color);font-size:clamp(2rem,5vw,3.8rem);line-height:1}.economic-global p{margin:0;color:var(--slate-800);font-size:1.12rem;font-weight:900}.economic-metrics .metric{border-color:var(--economic-border,var(--slate-200));background:linear-gradient(180deg,var(--economic-bg,#fff),#fff)}.economic-metrics .metric strong,.economic-metrics .metric .metric-note{color:var(--economic-color,var(--blue-950))}.metric-note{display:block;margin-top:5px;font-size:.82rem;font-weight:850}.economic-quality{display:grid;grid-template-columns:minmax(0,1fr) minmax(220px,.4fr);gap:16px;align-items:center;margin:18px 0;padding:18px;border:1px solid var(--slate-200);border-radius:20px;background:#fff}.economic-quality-bar{display:flex;height:22px;overflow:hidden;border-radius:999px;background:#f1f5f9;border:1px solid var(--slate-200)}.economic-quality-ok{background:#0f766e}.economic-quality-missing{background:#f59e0b}.economic-cell{font-weight:900}.economic-cell.economic-positive{color:#047857}.economic-cell.economic-negative{color:#be123c}.economic-cell.economic-neutral{color:#475569}.economic-cell.economic-warning{color:#b45309}.economic-ranking{border-color:var(--economic-border);background:linear-gradient(180deg,var(--economic-bg),#fff)}
@media (max-width:900px){.economic-quality{grid-template-columns:1fr}}